IndraLab

Statements

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"The results of flow cytometry and Tunel assay experiments showed that Kv1.5 silencing induced apoptosis significantly, in contrast to several results reported previously [XREF_BIBR]."
26569226
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"Overexpression of human KCNA5 increases IK V and enhances apoptosis."
15140747
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"The future approaches using Kv1.5 conditional knockout mice or other technologies are required to explore the effect of Kv1.5 in vivo.In summary, the present study has demonstrated that palmitate incr[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Furthermore, studies have demonstrated that KCNA5 gene transfer, in addition to increasing K currents, increased caspase-3 activity and accelerated apoptosis."
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"Similarly, transfection of KCNA5 into isolated rat PASMCs increased K current and enhanced apoptosis [85]."
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"To determine whether KV1.5 mediates the impact of apigenin on mitochondria-dependent apoptosis of hypoxic PASMCs, we examined the effects of DPO-1 (1 μm), a protein known to be a specific KV1.5 inhibi[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
31930969
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"Evidence of the pathogenic importance of disordered O -sensing pathways in PAH includes the observations that therapeutic overexpression of Kv1.5 (Michelakis et al., 2001; Brevnova et al., 2004; Bonnet et al., 2006) or dominant negative HIF-1α inhibition (Bonnet et al., 2006) restores PASMC membrane polarity and apoptosis in vitro."
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"Thus, we propose that apigenin targets KV1.5 and then results in the modulation of PASMC apoptosis via a mitochondria-dependent pathway.Previous studies have revealed that HIF-1α activates the transcr[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Taken together, these results suggest that Kv1.5 could induce osteosarcoma cell apoptosis through regulation of Bcl-2 family proteins."
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"The objective of this study was to test the hypothesis that overexpression of KCNA5, which encodes a delayed-rectifier voltage gated K+ (Kv) channel, increases K+ currents and enhances apoptosis."
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"Notably, the overexpression of human KCNA5 gene encoding Kv1.5 channels increases Kv current and enhances apoptosis ( Brevnova, Platoshyn, Zhang, & Yuan, 2004 )."
33744261
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"Overexpression of the human KCNA5 gene increases K+ currents (i.e., K+ efflux or loss), accelerates apoptotic volume decrease (AVD), increases caspase-3 activity, and induces apoptosis."
15140747
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"Overexpression of Kv1.5 channel in human PASMC and other cell lines (HEK-293, CHO and COS cells) causes membrane hyperpolarization and enhances apoptosis ( Brevnova et al., 2004 )."
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"Furthermore, we carried out flow cytometer experiments to evaluate the involvement of Kv1.5 in palmitate-induced apoptosis in HUVECs."
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"We found that palmitate increased Kv1.5 protein expression in concentration-dependent manners, along with increasing apoptosis; while silencing of Kv1.5 inhibited palmitate-induced endothelial apoptos[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"KCNA5 overexpression increased the induced apoptosis."
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"Silencing of Kv1.5 significantly inhibited palmitate-induced reduction of cell viability, apoptosis and excessive ROS generation, suggesting that silencing of Kv1.5 has protective effects on endotheli[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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