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Iron atom inhibits KCNH2. 3 / 3
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"In general, Erg1 downregulation by iron chelation causes an increase in terbinafine susceptibility, although the degree of susceptibility varies among the strains."
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"Consistent with a decrease in Erg1 levels, yeast cells displayed an enhanced sensitivity to terbinafine upon chemical or genetic iron deficiency that was rescued by ectopically overexpressing ERG1 (Figures 1E, 2)."
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"In addition, the two iron chelators desferrioxamine (1 mm) and o-phenanthroline (0.2 mm) significantly inhibited hERG1 outward K (+) currents and prevented hERG1 inhibition induced by the ROS scavenging enzyme catalase (1000 units/ml)."
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