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VIRF-4 inhibits USP7. 2 / 2

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"In summary, our study shows that vIRF4 derived short vif1 and vif2 peptides comprehensively suppress HAUSP activity, effectively restoring p53 dependent apoptosis in wild-type p53 carrying cancer cells and suppressing tumor growth in a mouse xenograft model."

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"An in vitro DUB assay of immunopurified Flag-HAUSP complexes with K48 linked 3-7 polyubiquitin chains showed that vIRF4 effectively suppressed HAUSP DUB activity in a binding dependent manner."

22056774

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IndraLab

Statements

VIRF-4 inhibits USP7. 2 / 2

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