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This Service

A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

VIRF-4 inhibits USP7. 2 / 2

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"In summary, our study shows that vIRF4 derived short vif1 and vif2 peptides comprehensively suppress HAUSP activity, effectively restoring p53 dependent apoptosis in wild-type p53 carrying cancer cells and suppressing tumor growth in a mouse xenograft model."

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"An in vitro DUB assay of immunopurified Flag-HAUSP complexes with K48 linked 3-7 polyubiquitin chains showed that vIRF4 effectively suppressed HAUSP DUB activity in a binding dependent manner."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...