IndraLab

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VIRF-4 inhibits USP7. 4 / 4
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"In summary, our study shows that vIRF4 derived short vif1 and vif2 peptides comprehensively suppress HAUSP activity, effectively restoring p53 dependent apoptosis in wild-type p53 carrying cancer cells and suppressing tumor growth in a mouse xenograft model."
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"An in vitro DUB assay of immunopurified Flag-HAUSP complexes with K48 linked 3-7 polyubiquitin chains showed that vIRF4 effectively suppressed HAUSP DUB activity in a binding dependent manner."
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"As an example, two vIRF4-derived peptides effectively suppress the DUB activity of USP7, leading to p53-dependent cell cycle arrest and tumor regression in mouse models [47]."
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"Further studies are needed to test this hypothesis.It is worth noting that KSHV vIRF1 and vIRF4 suppress the DUB activity of USP7 to inhibit p53 and promote tumorigenesis [46, 47], whereas USP7 DUB activity is required for K-RTA stability and efficient viral replication during KSHV lytic reactivation."
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