IndraLab

Statements

OTUB1 inhibits IRF3. 3 / 4
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"The overexpression of OTUB1 inhibited virus induced activation of IRF3 and NF-kappaB, whereas knockdown of OTUB1 had the opposite effects."
27999186
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"[172] Because various components are involved in virus induced signaling, biochemical assays have demonstrated that OTUB1 and OTUB2 inhibit RIG-I-, MDA5-, and MAVS mediated but not TBK1- and IRF3 mediated signaling."
33511009
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"Overexpression of OTUB1 and OTUB2 inhibited virus induced activation of IRF3 and NF-kappaB, transcription of the IFNB1 gene as well as cellular antiviral response, whereas knockdown of OTUB1 and OTUB2 had opposite effects."
19996094