IndraLab

Statements

USP48 inhibits HMGA2. 4 / 4
| 4
reach
"Interestingly, the small-molecule inhibitor targeting USP48 induces destabilization of HMGA2."
38572092
reach
"The findings suggest that SUMOylation of USP48 significantly enhances its ability to stabilize HMGA2 and promote CRC invasion and metastasis in a HMGA2-dependent manner.3.6 DUB-IN-2 hinders the deubiquitinating activity of USP48 and induces the degradation of HMGA2."
38572092
reach
"We then demonstrate that inhibition of USP48 by shRNA or its newly discovered inhibitor DUB-IN-2 triggers HMGA2 degradation, thereby inhibiting CRC cell metastasis in vitro and in vivo."
38572092
reach
"The enforced expression of USP48 significantly increased HMGA2 protein levels by inhibiting its degradation, while the deprivation of USP48 promoted HMGA2 degradation, thereby suppressing tumor invasion and metastasis."
38572092