IndraLab

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USP4 binds MAP3K7. 20 / 26
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"USP4 binds to overexpressed TAK1 with TAB1 and TNFα induces association of USP4 with TAK1."
21331078
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"To further determine the molecular interaction of USP4 and TAK1 in TNFα-induced signal transduction, we overexpressed expression vector encoding MYC-USP4 in HEK-293T cells and treated with TNFα for the time points as indicated ( xref )."
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"USP4 and USP18 bind with TAK1 and de-ubiquitinate TAK1 to inhibit its activation [10, 12]."
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"Tumour necrosis factor-α (TNFα) promotes the interaction between USP4 and TAK1 and the deubiquitination of TAK1, leading to the attenuation of TAK1-mediated NF-κB activation."
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"Furthermore, unlike CYLD, binding of USP4 with TAK1 is induced by TNFα stimulation in the cells ( xref )."
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"To verify the mass spectrometry results, a Co-IP assay was performed to test the reciprocal interaction between USP4 and TAK1 in ESCC cells."
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"TNFα induces association of USP4 with TAK1 to deubiquitinate TAK1 and downregulate TAK1-mediated NF-κB activation."
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"In conclusion, our results provide evidence that TNFα induces association of USP4 with TAK1 which leads to TAK1 deubiquitination in the TNFα-mediated NF-κB activation."
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"In view of the data presented here and previous reports, we propose a working model ( xref ), in which that TNFα rapidly induces Lys63-linked TAK1 polyubiquitnation and binding of USP4 to TAK1, Lys63-linked TAK1 would be rapidly deubiquitinated by USP4 to attenuate the magnitude of TNFα-induced Lys63-linked TAK1 polyubiquitination and TAK1-mediated IKK/NF-κB activation."
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"In addition, USP4-TAK1 interaction and subsequent TAK1 deubiquitination were required for the amelioration of metabolic dysfunctions."
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"Tumour necrosis factor-alpha (TNFalpha) promotes the interaction between USP4 and TAK1 and the deubiquitination of TAK1, leading to the attenuation of TAK1 mediated NF-kappaB activation."
27155333
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"It was shown that TNFα induces the association of USP4 with TAK1 and deubiquitylation of K63-linked ubiquitin chains from TAK1, leading to the inhibition of NF-κB production."
25007997
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"The association between USP4 and TAK1 were also confirmed by co-immunoprecipitation of overexpressed FLAG-TAK1 and TAB1 and HA-USP4 in HEK-293T cells (XREF_FIG)."
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"To further determine the molecular interaction of USP4 and TAK1 in TNFalpha induced signal transduction, we overexpressed expression vector encoding MYC-USP4 in HEK-293T cells and treated with TNFalpha for the time points as indicated (XREF_FIG)."
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"Furthermore, TNFalpha induced recruitment of USP4, TAK1 and RIPK1 to TNFR1 (XREF_FIG)."
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"Furthermore, unlike CYLD, binding of USP4 with TAK1 is induced by TNFalpha stimulation in the cells (XREF_FIG)."
21331078
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"These results suggest that TNFα induces association of USP4 with TAK1."
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"Studies by the same group reported that the USP4-TAK1 axis is a potential therapeutic target for cardiac remodeling, a common MASLD-associated cardiac disorder [ xref ]."
40133964
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"To further determine the specificity of association of USP4 with TAK1, we co-transfected FLAG-TAK1 and TAB1 expression vectors into HEK-293T cells along with vector control, expression vectors encoding MYC-USP4 full length (USP4-WT), N-terminal regulatory domain (1–301 aa, USP4-NT), N-terminal Serine-rich domain and USP domain (188–963 aa, USP4-CTL), or C-terminal USP domain (302–963 aa, USP4-CTS), respectively ( xref )."
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"Recently, it has been shown that USP4 binds TAK1 for deubiquitination and negatively regulates NF-κB activation in mammals; Fan et al. reported that mammalian USP4 functions as a TAK1 DUB that deubiqu[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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