IndraLab

Statements

USP6 activates JAK1. 3 / 3
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"Jak1 in this clone was reduced to levels approximating those in control NIH3T3 cells (XREF_SUPPLEMENTARY), demonstrating that upregulation of Jak1 by USP6 is required for full activation of STAT3 by USP6."
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"Jak1 is upregulated by USP6 in a USP dependent manner."
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"Together, this group of experiments indicates that upregulation of Jak1 by USP6 is required not only for the production of autocrine and paracrine factors, but also for heightened STAT3 activation in response to them."
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