IndraLab

Statements

KCNQ1 activates SLC5A3. 5 / 5
| 5
reach
"Future investigations will be targeted at understanding exactly how KCNQ1 augments SMIT1 and NIS activity and whether there are underlying mechanistic commonalties."
27098917
reach
"KCNQ1 specific inhibitors also inhibit co-assembled SMIT1 activity, suggesting that K + efflux through KCNQ1 helps SMIT1 bring in more substrate, but only when the KCNQ1 conformation is amenable."
32655402
reach
"While KCNQ1 co-expression enhanced SMIT1 myo-inositol uptake, KCNQ1-KCNE2 inhibited it, as did co-expression with R231A-KCNQ1, a constitutively active mutant with the VSD locked in the active state [XREF_BIBR]."
28718502
reach
"KCNQ1 specific inhibitors also inhibit co-assembled SMIT1 activity; this suggests that as would be expected, K + efflux through KCNQ1 does help SMIT1 bring in more substrate, but only when the KCNQ1 conformation is amenable."
26123744
reach
"SMIT1 enhances KCNQ1 currents; KCNQ1 augments SMIT1 transport activity, but co-expression of both KCNE2 and KCNQ1 strongly inhibits SMIT1 activity."
30959022