IndraLab

Statements

STAM activates STAMBP. 11 / 12
| 6 5
sparser
"In the current article, we aspire to understand if any particular structural organization forms a basis for the activation of AMSH by STAM and allows a better efficiency of its enzymatic process towar[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
27725184
sparser
"Next, we compared the K63-diUb (FRET) cleavage inhibition by the UbVs with STAMBP JAMM to the inhibition of full-length STAMBP activated by STAM protein and full-length STAMBPL1."
34425109
sparser
"While either deletion or mutation of the STAM-UIM or -SH3 domain prevents the activation of AMSH by STAM (see Fig. 1 a for structural details) [25] , we were seeking to understand if and how Lys63-Ub [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
27725184
sparser
"In addition, we observed inhibition of STAM1-activated full-length STAMBP by both UbV SP."
34425109
reach
"It has been reported that pre-incubation with STAM stimulates AMSH 's DUB activity on tetra-Ubs, which supports our data strongly [25]."
17078930
reach
"In the current article, we aspire to understand if any particular structural organization forms a basis for the activation of AMSH by STAM and allows a better efficiency of its enzymatic process towar[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
27725184
reach
"We propose a possible organization where the plasticity of STAM2, combined with the flexibility of AMSH, allows its possible interaction with Lys63-linked polyubiquitin chains and induces further chai[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
27725184
sparser
"As can be seen, the foundation of the AMSH activation by STAM has been explored by means of different biological assays."
27725184
reach
"As can be seen, the foundation of the AMSH activation by STAM has been explored by means of different biological assays."
27725184
reach
"We propose that STAM fulfills an adaptor function for AMSH and that there might be a correspondingly diverse set of DUB and adaptor combinations.The ability of STAM to directly stimulate AMSH activity[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
16431367
reach
"In addition, STAM directed AMSH cleavage toward the distal isopeptide bond in tri-ubiquitin chains."
26601948