IndraLab

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Pyraclofos activates CACNA1A. 9 / 9
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"Thus, it is possible that vesicles associated with full-length SNAP-25 but not SNAP-25 contribute to spontaneous fusion events, whereas the increased Ca levels associated with evoked release are required to recruit SNAP-25 (Beske et al., 2018), thus contributing to the difference in recovery between evoked release and spontaneous release in motor neurons intoxicated by BoNT/A.Vesicle fusion is mediated by three high voltage-activated VGCCs distinguished by the alpha subunit (Dolphin, 2016): P/Q-type (CaV2.1), L-type (CaV1), and N-type (CaV2.2)."
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"This subsystem is differentiated by the expression of the voltage-activated calcium (Cav) channel subunit Cav2.1 (also known as α1A, encoded by the gene Cacna1a in mice)."
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"The MWC model soon was adapted to account for the agonist activation of the nicotinic acetylcholine receptors (nAChRs) ( xref ), and a version of the KNF model, in which the T↔R equilibrium varies as a function of the membrane potential difference, has been extensively used to account for the voltage activation of voltage-dependent channels."
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"This subsystem is differentiated by the expression of the voltage-activated calcium (Cav) channel subunit Cav2.1 (also known as α1A, encoded by the gene Cacna1a in mice)."
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"Although the exact mechanism of action of Verapamil is not well known in RBCs, it is more likely that it acts on voltage-activated Ca 2+ channel (CaV2.1) ( Johnson et al., 1996 ; Freeze et al., 2006 )[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"The VGCC family includes both low voltage activated T-type (Cav3.1-3.3) Ca 2+ channels and high voltage activated L-type (Cav1.1-1.4), N-type (Cav2.2), P/Q-type (Cav2.1) and R-type (Cav2.3) Ca 2+ chan[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Interestingly, Izquierdo-Serra et al. [ 19 ] found similarities between PMM2-CDG and channelopathies related to familial hemiplegic migraine (FHM), as caused by mutations in CACNA1A, encoding a subuni[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"EA2 is the most commonly occurring episodic ataxia, and is caused by heterozygous mutations in calcium channel, voltage-dependent, P/Q type, alpha 1A subunit gene ( CACNA1A )."
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"In contrast, Cav2.1 (P/Q-type) is activated by high voltage and Cav2.1-dependent ADF is expected to affect only the very proximal part of the axon ( Fig. 5 )."
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