IndraLab

Statements

USP8 translocates to the endosome. 13 / 13
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"In yeast, this deubiquitination step is carried out by the DUB hydrolase, Doa4 [66] , while in mammals the situation is more complex: two DUBs, USP8 (Ub Specific Protease 8, also called UBPY) and AMSH[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"AMSH and UBPY are recruited to endosomes by interactions between their N-terminal MIT domains and late-acting ESCRT-III subunits [ 54–56,57 • ,59 ]."
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"STAM also interacts with and recruits USP8 to the endosome, resulting in the deubiquitination of EGFR [ 16 ]."
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"UBPY translocates to endosomes following acute EGF stimulation, whereas a catalytically inactive mutant is constitutively associated with endosomal membranes, where it promotes accumulation of ubiquit[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Finally, USP8 and AMSH (associated molecule with the SH3 domain of STAM), two DUBs that are usually recruited to endosomes, have an important role in cytokinesis."
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"How is the endosomal recruitment of USP8 related to its function in endolysosomal trafficking process?"
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"Recruitment of both AMSH and USP8 to endosomes relies on binding to a distinct, but overlapping set of ESCRT III proteins via their respective MIT domains [168,173,174] ."
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"On the other hand, human USP8 recruitment to the endosomes is dependent on its N-terminal MIT (microtubule interacting and transport) domain that associates with components of the ESCRT XREF_BIBR."
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"We investigated in more detail how UBPY bound HD-PTP Bro1-V. We focused on the N-terminal MIT domain of UBPY, which also binds CHMP4B, because this is essential for recruiting UBPY to endosomes and su[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"USP8 is recruited to endosomes upon EGF stimulation but shows no association with endosomes in starved cells in contrast to AMSH ( xref )."
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"We focused on the N-terminal MIT domain of UBPY, which also binds CHMP4B, because this is essential for recruiting UBPY to endosomes and supporting EGFR degradation [19]."
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"USP8 is recruited to endosomes upon EGF stimulation but shows no association with endosomes in starved cells in contrast to AMSH."
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"Given that ErbB receptors are present on endosomal membranes, we hypothesized that MIT-dependent endosomal recruitment of Usp8 is required for Usp8 tyrosine phosporylation."
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