IndraLab

Statements

USP8 translocates to the endosome. 7 / 7
| 4 3
reach
"We focused on the N-terminal MIT domain of UBPY, which also binds CHMP4B, because this is essential for recruiting UBPY to endosomes and supporting EGFR degradation [19]."
23477725
reach
"USP8 is recruited to endosomes upon EGF stimulation but shows no association with endosomes in starved cells in contrast to AMSH."
16702236
reach
"On the other hand, human USP8 recruitment to the endosomes is dependent on its N-terminal MIT (microtubule interacting and transport) domain that associates with components of the ESCRT XREF_BIBR."
20838651
sparser
"Given that ErbB receptors are present on endosomal membranes, we hypothesized that MIT-dependent endosomal recruitment of Usp8 is required for Usp8 tyrosine phosporylation."
21044682
sparser
"USP8 is recruited to endosomes upon EGF stimulation but shows no association with endosomes in starved cells in contrast to AMSH ( xref )."
16702236
sparser
"We investigated in more detail how UBPY bound HD-PTP Bro1-V. We focused on the N-terminal MIT domain of UBPY, which also binds CHMP4B, because this is essential for recruiting UBPY to endosomes and su[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
23477725
reach
"Finally, USP8 and AMSH (associated molecule with the SH3 domain of STAM), two DUBs that are usually recruited to endosomes, have an important role in cytokinesis."
28900014