IndraLab

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USP12 activates IFI16. 4 / 4
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"These findings promote the understanding of varied regulation of USP12 in antiviral signaling.In summary, we reported that USP12 promoted IFI16-mediated innate antiviral signaling."
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"Fu et al. [49] discovered that USP12 promoted IFI16-mediated innate antiviral signaling."
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"By contrast, USP12 enhanced IFN-β, NF-κB, and ISRE promoter activities in a dose-dependent manner after cotransfection with IFI16 (Fig 4B)."
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"Notably, USP12-mediated ISG response was independent of IFI16 as either IFI16 deficiency in BMDMs or overexpression in Usp12 BMDMs had no impact on ISG transcription."
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