IndraLab

Statements

reach
"Consequently, the recruitment of adaptors, MyD88 and TRIF, to TLR4 is attenuated in cells treated with DHA, leading the diminished expression of inflammatory genes such as TNF-alpha and COX-2."
27085899
reach
"In the PMEC experiment, compared with the control, increased mRNA abundances of Toll like receptor (TLR) -4 downstream target, myeloid differentiation factor 88 (MyD88), IL-6 and IL-8 were observed in LPS treatment, whereas DHA appeared to decrease mRNA abundances of MyD88, IL-6 and IL-8 induced by LPS."
27938408
reach
"DHA also suppressed NFkappaB activation induced by TLR4 (CA), but not MyD88 (CA) or AKT (CA), suggesting that the molecular targets of DHA are signaling components upstream of MyD88 and AKT."
12865424