IndraLab

Statements

PKP3 activates OTUB1. 7 / 7
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"PKP3-mediated OTUB1 upregulation further elevates the expression of PD-L1 by facilitating its deubiquitination.69 Therefore, the regulatory effect possessed by circIGF2BP3 on PKP3/OTUB1/PD-L1 axis may provide a novel mechanism for conquering immune escape in treating NSCLC."
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"PKP3 upregulates OTUB1 expression by increasing OTUB1 mRNA stability To test whether PKP3-mediated OTUB1 upregulation is posttranscriptional or transcriptional , we constructed and transfected a luciferase reporter plasmid containing a promoter fragment of OTUB1 into NSCLC cells stably overexpressing PKP3 ."
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"PKP3-mediated OTUB1 upregulation in turn alleviates PD-L1 ubiquitination and subsequent proteasomal degradation."
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"Taken together , these findings indicate that PKP3 upregulates OTUB1 expression at the posttranscriptional level rather than at the transcriptional level , possibly by increasing the stability of OTUB1 mRNA ."
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"To test whether PKP3-mediated OTUB1 upregulation is posttranscriptional or transcriptional, we constructed and transfected a luciferase reporter plasmid containing a promoter fragment of OTUB1 into NSCLC cells stably overexpressing PKP3."
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"Moreover, PKP3 markedly prevented OTUB1 mRNA degradation (Fig. 7B)."
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"PKP3 promotes OTUB1 expression by enhancing its mRNA stability ."
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