IndraLab

Statements

Akap5 binds KCNK2. 8 / 8
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sparser
"The association of AKAP150 with TREK channels integrates them into a postsynaptic scaffold where both G-protein-coupled membrane receptors (as demonstrated here for beta2AR) and TREK-1 dock simultaneously."
17110924
sparser
"36 The membrane-anchoring protein AKAP150 also interacts with TREK channels in this domain to change gating behavior."
19084539
sparser
"AKAP150 binding to the post M4 region of TREK-1 transforms low-activity outwardly rectifying currents into robust leak conductances insensitive to arachidonic acid, stretch and acidification."
19084539
reach
"3.4.1 TREK Channel Interactions with AKAP150 and Mtap2."
21358977
sparser
"Furthermore, the association of AKAP150 with TREK1 channels integrates them into postsynaptic scaffolds where G protein-coupled membrane receptors and channels dock simultaneously."
18998088
reach
"Mtap2 and AKAP150 can bind to TREK-1 simultaneously and modulate the channel synergistically."
26772438
reach
"Inhibition of the TREK-1/AKAP150 complex by Gs-coupled receptors such as serotonin 5HT4sR and noradrenaline beta2AR is as extensive as for TREK-1 alone, but is faster."
17110924
sparser
"Recently, we demonstrated that A-kinase anchoring protein AKAP150 binds to a major regulatory domain of TREK-1, promoting drastic changes in channel regulation by polyunsaturated fatty acids, pH, and stretch, and by G-protein-coupled receptors to neurotransmitters and hormones."
18716213