IndraLab

Statements

KCNK2 binds Akap5. 6 / 6
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"3.4.1 TREK Channel Interactions with AKAP150 and Mtap2."
21358977
sparser
"Recently, we demonstrated that A-kinase anchoring protein AKAP150 binds to a major regulatory domain of TREK-1, promoting drastic changes in channel regulation by polyunsaturated fatty acids, pH, and stretch, and by G-protein-coupled receptors to neurotransmitters and hormones."
18716213
reach
"Inhibition of the TREK-1/AKAP150 complex by Gs-coupled receptors such as serotonin 5HT4sR and noradrenaline beta2AR is as extensive as for TREK-1 alone, but is faster."
17110924
sparser
"The association of AKAP150 with TREK channels integrates them into a postsynaptic scaffold where both G-protein-coupled membrane receptors (as demonstrated here for beta2AR) and TREK-1 dock simultaneously."
17110924
sparser
"Furthermore, the association of AKAP150 with TREK1 channels integrates them into postsynaptic scaffolds where G protein-coupled membrane receptors and channels dock simultaneously."
18998088
reach
"Mtap2 and AKAP150 can bind to TREK-1 simultaneously and modulate the channel synergistically."
26772438