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Superoxide inhibits CASP1. 5 / 5
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eidos
"An early study showed that in superoxide dismutase 1 ( SOD1 ) - deficient macrophages , higher superoxide production specifically inhibits caspase-1 via thiol glutathionylation of cysteine residues Cys-397 and Cys-362 [ 99 ] ."
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reach
"For example, researchers have not clarified whether the mechanism by which superoxide directly inhibits caspase-1 activity by regulating redox sensitive cysteines provides dose- or temporal dependent negative feedback to limit the function of caspase-1 triggered by a ROS dependent NLRP3 pathway."
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"In addition, procaspase-1 could be directly inhibited by superoxide [ xref ]."
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eidos
"For example , researchers have not clarified whether the mechanism by which superoxide directly inhibits caspase-1 activity by regulating redox-sensitive cysteines ( 78 ) provides dose - or temporal-dependent negative feedback to limit the function of caspase-1 triggered by a ROS-dependent NLRP3 pathway ."
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reach
"Accordingly, oxidative inactivation of Caspase-1 by superoxide anions (Meissner et al., 2008) and the inhibition of NLPR3 by nitric oxide (Hernandez-Cuellar et al., 2012; Mao et al., 2013; Mishra et a[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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