IndraLab

Statements

USP8 deubiquitinates GPX4. 3 / 3
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"Specifically, we reveal that USP8 deubiquitinates glutathione peroxidase 4 (GPX4), safeguarding it from proteasome-mediated degradation."
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"USP8 interacts with and deubiquitinates GPX4, thereby preventing GPX4 protein degradation."
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"Furthermore, ectopic expression of USP8 dramatically reduced the ubiquitination of GPX4 WT, K125R, K127R, and K151R mutants, but it failed to remove the ubiquitination of the GPX4 K48R mutant (SI Appendix, Fig. S4U)."
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