IndraLab
Statements
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"In a related example, the tRNA methyltransferase known as TrmH which is required for G18 tRNA Nm, is not present in most bacteria, however, specific Nm modification to guanosine in bacterial tRNA position 18 is required to inhibit Toll-like receptor 7-mediated immune activation during a human host–pathogen response episode [191, 192]."
reach
"Nonetheless, our data suggest that human TLR7 activation can be inhibited by guanosine methylation in RNA63, irrespective of the position, whereas TLR8 activation remains unaffectedIn mice, TLR7 can also induce both IFN-α and IL-6 release, whereas TLR8 activation does not induce these cytokines [9,10,12,13]."