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LY294002 inhibits IFNB1. 7 / 9
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"On the other hand, an IRF inhibitor, LY294002, which targets IFN-beta production via IRF3 inhibition, has been shown to sensitize cancer cells to chemotherapy in cervical cancer cells by enhancing mitochondrial JNK signaling."
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"Furthermore, IFNbeta production was almost completely inhibited by LY294002."
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"In turn, LY294002 reduces the activation of IFN-beta reporter genes within murine macrophages, subsequently inhibiting its production [XREF_BIBR]."
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"As shown in XREF_FIG, while LY294002, an inhibitor of PI3K that is essential for activation of IRF3 by RIG-I and MDA5 XREF_BIBR, dose-dependently inhibited IFN-beta promoter driven luciferase expression (XREF_FIG), RO 90-7501 significantly enhanced the IFN-beta promoter activation by cytoplasmic delivered poly I : C (XREF_FIG)."
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"Both TNF-alpha and IFN-beta protein concentrations were also reduced significantly by LY294002 treatment, while IFN-beta mRNA level was modestly downregulated."
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"IFN-β promoter-driven luciferase activity was gradually reduced by the PI3K-specific inhibitor, LY294002 [50] , in a dose-dependent manner in JEV- ( Fig. 8 A) and DEN-2-infected cells ( Fig. 8 B)."
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"We demonstrated that LY294002 targets molecules downstream of TBK1 to inhibit IFN-β promoter activation."
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