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Celastrol inhibits NLRP3. 22 / 22
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"These results suggest that celastrol inhibits NLRP3 inflammasome activation in part by suppression of ROS production."
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"These results demonstrate that enhanced autophagy by celastrol contributes to celastrol mediated NLRP3 inflammasome inhibition."
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"Moreover, celastrol treatment markedly decreased mRNA expression caspase-1, NLRP3 and ASC in colon tissue."
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"Additionally, Celastrol displays considerable anti-inflammatory activity (De Seabra Rodrigues Dias et al., 2017; Zhang et al., 2018) and can inhibit cellular inflammation by suppressing NLRP3 activity (Yu et al., 2017)."
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"In summary, our findings demonstrate that celastrol inhibits NLRP3 inflammasome activation through autophagy activation."
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"Importantly, we observed that pretreatment of 3-MA enhanced IL-1beta production and reversed celastrol induced NLRP3 inflammasome inhibition (XREF_SUPPLEMENTARY, Figure XREF_FIG and XREF_FIG)."
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"We thus sought to determine whether celastrol could inhibit NLRP3 inflammasome activation by promoting autophagy."
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"As celastrol has multiple effects on inflammation, then we sought to determine whether celastrol inhibit NLRP3 inflammasome activation in other immune cells, apart from murine peritoneal macrophages."
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"Here, we show that celastrol abolishes the NLRP3 inflammasome activation, inhibits subsequent caspase-1 activation and IL-1beta secretion both in vitro and in vivo."
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"Celastrol suppressed NLRP3 inflammasome activation and alleviated P. acnes and LPS induced liver damage and MSU induced gouty arthritis."
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"Celastrol driven autophagy mediates NLRP3 inflammasome inhibition."
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"Interestingly, both NAC and Mito-TEMPO significantly inhibited IL-1beta secretion, implying that celastrol inhibited NLRP3 inflammasome partially through decreasing ROS production."
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"Celastrol inhibits ox-LDL-induced NLRP3 inflammasome activation in mesangial cells suggesting a possible contribution of celastrol mediated NLRP3 inhibition to proliferative glomerular diseases."
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"These data suggest that celastrol inhibits NLRP3 inflammasome activation through disrupting NLRP3 mediated ASC complex formation."
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"Celastrol inhibits NLRP3 inflammasome activation induced by both ATP and nigericin."
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"Intriguingly, 3-MA treatment could impair celastrol induced NLRP3 inflammasome inhibition, indicating that autophagy plays a critical role in celastrol induced NLRP3 inflammasome inhibition in systemic inflammation."
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"Celastrol specifically inhibits the activation of NLRP3 inflammasome."
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"Celastrol significantly suppresses inflammation by reducing the secretion of IL-1beta and IL-18, and inactivating the NLRP3 inflammasomes and caspase-1 in LPS and ATP primed macrophage cells."
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"Celastrol also significantly reduced the NLRP3 , IL-18 , and IL-1beta levels , together with macrophage and neutrophil infiltration in the myocardium ."
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"As expected, LPS treated wild type mice has decreased survival, compared with celastrol treated mice or Caspase-1 (TM)/(TM) mice, implying that celastrol can attenuate NLRP3 inflammasome activation in this model."
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"Celastrol relieves myocardial infarction-induced cardiac fibrosis by inhibiting NLRP3 inflammasomes in rats."
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"Celastrol inhibits NLRP3 inflammasome activation in various stimulus and different cell types."
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