IndraLab
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"For example, OTUB2 could bind to and deubiquitinate U2AF1 and then promote NSCLC progression via the AKT/mTOR pathway. xref Hyperbaric oxygen therapy and microRNA 101 have also been proven to repress the Warburg effect by HIF‐1α in NSCLC cells. xref , xref However, the inhibition is still weak, and therefore, a deeper understanding of the mechanisms underlying the Warburg effect is essential to intercept the energy supply and consequently inhibit NSCLC proliferation."
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"In NSCLC, numerous factors have been proven to be related to the Warburg effect: OTUB2 could bind to and deubiquitinate U2AF1 and consequently promote NSCLC progression, xref and α‐Hederin could inhibit glycolysis in A549 and H460 cells by activating SIRT6. xref Our previous study showed that AMPK could be located on the mitochondria, and this mitoAMPK could inhibit the Warburg effect."