IndraLab

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USP46 increases the amount of methane. 4 / 4
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"These findings revealed that the Usp46 complex increased Arrow levels at the cell surface (Fig. 8C)."
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"These results provide evidence that Arrow deubiquitylation by the Usp46 complex increases Arrow levels at the cell surface and thereby promotes Wingless signaling (Fig. 8D)."
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"By reducing Arrow/LRP6 ubiquitylation and turnover and thus increasing cell surface Arrow levels, Usp46 enhances the sensitivity of target cells to Wingless stimulation."
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"By reducing Arrow ubiquitylation and turnover, the Usp46 complex increases cell surface levels of Arrow and enhances the sensitivity of target cells to stimulation by the Wingless morphogen, thereby increasing the amplitude and spatial range of signaling responses."
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