IndraLab

Statements

USP10 increases the amount of AICDA. 3 / 3
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"c The fluorescence-field micrograph of identified AID-interacting deubiquitinase siRNA screen showed that USP10 knockdown dramatically decreased AID-GFP levels."
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"These results suggest that USP10 knockout in B cells decreases AID expression in B cells, thereby, decreasing IgG1 and IgA class-switch.AID is required for SHM and antibody affinity maturation."
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"The deficiency of USP10 in B cells significantly decreased AID protein levels, subsequently reducing neutralizing antibody production after immunization with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) or human immunodeficiency virus type 1 (HIV-1) nanoparticle vaccines."
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