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A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

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INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

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Statements

TLR4 activates USP18. 2 / 2

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"We similarly observed the rapid upregulation of USP18 after treatment with IFN-beta In addition, we found USP18 is upregulated by TLR2, TLR4, and TLR7/8 ligands in THP-1 cells."

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"The LPS mediated TLR4 activation in human macrophages upregulates USP18, which in turn inhibits NF-kappaB activation, and thus the secretion of proinflammatory cytokines (TNF-alpha, IL-6, and IL-1beta) via interacting with TAK1-TAB1 and IKKalpha and beta-NEMO complexes [193]."

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INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...