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TLR4 activates USP18. 2 / 2
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reach
"We similarly observed the rapid upregulation of USP18 after treatment with IFN-beta In addition, we found USP18 is upregulated by TLR2, TLR4, and TLR7/8 ligands in THP-1 cells."
26240016
reach
"The LPS mediated TLR4 activation in human macrophages upregulates USP18, which in turn inhibits NF-kappaB activation, and thus the secretion of proinflammatory cytokines (TNF-alpha, IL-6, and IL-1beta) via interacting with TAK1-TAB1 and IKKalpha and beta-NEMO complexes [193]."
| DOI