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USP10 deubiquitinates CFTR. 13 / 14
1 | 13
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"Cif stabilizes a G3BP1:USP10 complex in lung cells which renders USP10 inactive and thus unable to deubiquitinate CFTR (20, 36, 71) ."
| DOI
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"Furthermore, USP10 has been reported to reverse the ubiquitination of WT-CFTR, enabling CFTR to bypass lysosomal degradation and return to the PM [105,107,109]."
37511222
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"Although it has been shown that USP10 deubiquitinates and degrades CFTR [64], Pesce et al. found that spautin-1 could not affect the expression of CFTR, indicating that spautin-1 affected CF progression in a USP10-independent manner."
35627217
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"We previously reported that the DUB USP10 deubiquitinates CFTR in early endosomes of human airway epithelial cells XREF_BIBR."
21455491
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"For example, Cif (PA2934), a virulence factor in OMVs, reduces USP10-mediated deubiquitination of CFTR by inactivating host cell deubiquitinating enzyme (USP10) and increases CFTR degradation in lysosomes, which inhibits chloride secretion and thus reduces the ability to clear respiratory pathogens through mucus cilia, an important component of the pulmonary innate immune response ( Figure 2 ) ( Bomberger et al., 2011)."
36569192
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"USP10 deubiquitinates CFTR in endosomes, thereby increasing the probability of endocytic recycling, which in turn helps to maintain the abundance of CFTR at the plasma membrane."
36183834
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"USP10 deubiquitinates CFTR in endosomes, thereby increasing the probability of endocytic recycling, which in turn helps to maintain the abundance of CFTR at the plasma membrane."
| DOI
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"USP10 decreases the ubiquitination of CFTR, whereas the knockdown of USP10 promotes the ubiquitination and reduction of CFTR at the cell surface [XREF_BIBR]."
| PMC
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"The ability of USP10 to efficiently deubiquitinate CFTR in the early endosome allows for efficient endocytic recycling of CFTR and thus the long half-life of CFTR (approximately 8-24 h in polarized human airway cells) in the plasma membrane."
20215869
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"Inhibition of USP10 suppresses post-endocytic de-ubiquitination of CFTR, and the cell targets the ion channel to the lysosome rather than recycling it into the apical membrane."
28392259
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"USP10, in particular, deubiquitinates ENaC and CFTR increasing their expression in cell membrane."
33095475
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"Functionally, Cif stabilizes an intracellular complex of a DUB (USP10) and G3BP1, preventing deubiquitylation of CFTR, which is required for recycling the receptor to the plasma membrane XREF_BIBR."
22927812
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"In a recent study, we demonstrated that USP10, a host cell DUB, deubiquitinates CFTR in endosomes, thereby reducing the lysosomal degradation of CFTR, and maintaining cell and plasma membrane CFTR XREF_BIBR."
21455491