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USP10 deubiquitinates CFTR. 11 / 11
1 | 10
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"Inhibition of USP10 suppresses post-endocytic de-ubiquitination of CFTR, and the cell targets the ion channel to the lysosome rather than recycling it into the apical membrane."
28392259
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"USP10 decreases the ubiquitination of CFTR, whereas the knockdown of USP10 promotes the ubiquitination and reduction of CFTR at the cell surface [XREF_BIBR]."
| PMC
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"USP10 deubiquitinates CFTR in endosomes, thereby increasing the probability of endocytic recycling, which in turn helps to maintain the abundance of CFTR at the plasma membrane."
| DOI
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"Functionally, Cif stabilizes an intracellular complex of a DUB (USP10) and G3BP1, preventing deubiquitylation of CFTR, which is required for recycling the receptor to the plasma membrane XREF_BIBR."
22927812
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"We previously reported that the DUB USP10 deubiquitinates CFTR in early endosomes of human airway epithelial cells XREF_BIBR."
21455491
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"Cif stabilizes a G3BP1:USP10 complex in lung cells which renders USP10 inactive and thus unable to deubiquitinate CFTR (20, 36, 71) ."
| DOI
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"Although it has been shown that USP10 deubiquitinates and degrades CFTR [64], Pesce et al. found that spautin-1 could not affect the expression of CFTR, indicating that spautin-1 affected CF progression in a USP10-independent manner."
35627217
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"In a recent study, we demonstrated that USP10, a host cell DUB, deubiquitinates CFTR in endosomes, thereby reducing the lysosomal degradation of CFTR, and maintaining cell and plasma membrane CFTR XREF_BIBR."
21455491
ubibrowser
"Review"
27775833
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"The ability of USP10 to efficiently deubiquitinate CFTR in the early endosome allows for efficient endocytic recycling of CFTR and thus the long half-life of CFTR (approximately 8-24 h in polarized human airway cells) in the plasma membrane."
20215869
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"USP10, in particular, deubiquitinates ENaC and CFTR increasing their expression in cell membrane."
33095475