IndraLab

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USP13 activates HYCC1. 17 / 17
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"In addition, implanting USP13 knockdown cells to nude mice showed that knockdown of USP13 significantly inhibited HCC tumor growth."
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"These results suggest that the USP13‐PRPF6 axis promotes HCC cell proliferation by regulating AKT‐mTOR signalling.3.6 USP13 Expression Is Correlated With PRPF6 in Human HCC Tissues."
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"Thus, USP13 deficiency suppressed HCC cell proliferation, migration, and stemness in vitro.To further validate the function of USP13 in HCC, we established USP13-overexpressing HCC cells via lentivirus (Supplementary Fig. S2A, B)."
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"68 While inhibiting USP13 significantly suppresses HCC and ovarian tumor progression is unknown whether these effects are mediated by ATP citrate lyase and oxoglutarate dehydrogenase."
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"Further investigation revealed that the knockout of USP13 inhibited HCC cell proliferation, whereas overexpression of USP13 had the opposite effect."
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"Further experimental results confirmed that the USP13‐PRPF6 axis promoted the proliferation of HCC cells by modulating the AKT‐mTOR signalling pathway.In conclusion, we have demonstrated that USP13 can decrease the K48/63‐linked polyubiquitination of PRPF6, thereby stabilising this protein and promoting HCC cell proliferation via regulation of the AKT‐mTOR pathway (Figure 8C)."
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"However, there is no evidence that the regulation of WWP1 deubiquitination serves as a substrate.In this study, we confirmed that USP13 was elevated in HCC and acted as an oncogene to enhance the malignant characteristics of HCC cells both in vitro and in vivo."
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"According to the results of the Transwell assay (Supplementary Fig. S2F) and wound healing assay (Supplementary Fig. S2G), USP13 promoted HCC cell migration."
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"3.1 USP13 Is Up-Regulated in HCC and Associated With Poor Prognosis."
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"Moreover, USP13 stabilized WWP1 by removing the K29- and K48-linked polyubiquitination chains from WWP1 and then activated the Akt/mTOR pathway in HCC."
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"To explore the expression of USP13 in tumor tissues, we analyzed USP13 expression through the Gene Expression Omnibus (GEO) and The Cancer Genomics Atlas (TCGA) databases, which revealed that USP13 mRNA was elevated in many human tumor tissues compared with normal tissues (Fig. 1A), including HCC (Fig. 1B, C; Supplementary Fig. S1A)."
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"As revealed by the CCK-8 (Supplementary Fig. S2C, D) and colony formation (Supplementary Fig. S2E) assays, USP13 overexpression enhanced HCC cell proliferation."
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"Together, our findings revealed that YY1 transcriptionally upregulated USP13 expression, indirectly increased WWP1 protein expression and promoted HCC progression."
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"USP13 promoted the growth of HCC tumors, since tumors in the USP13 group were larger than those in the NC group."
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"USP13 promoted HCC cell growth and metastasis by regulating the TLR4/MyD88/NF-κB pathway [37]."
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"However, how USP13 accelerates HCC development remains to be elucidated."
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"To confirm USP13 accelerates the proliferation of HCC cells through regulating PRPF6‐AKT‐mTOR signalling, we performed the rescue experiments by silencing PRPF6 in USP13 up‐regulated cells."
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