IndraLab

Statements

Mutated CACNA1C activates calcium(2+). 3 / 3
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"Changes in I CaL, sodium-calcium exchanger current (I NCX), I rel, cytoplasmic calcium concentration ([Ca2+] i) and SR calcium concentration ([Ca2+] SR) were used to analyze CACNA1C mutations induced calcium handling."
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"Third, the CACNA1C mutation increased intracellular calcium concentration, which influenced cardiac mechanics."
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"It has been demonstrated that CACNA1C mutations caused a gain-of-function of Ca V 1.2 L-type calcium channel, leading to an increased calcium influx, resulting in a dramatic AP prolongation XREF_BIBR XREF_BIBR XREF_BIBR and afterdepolarization triggered activity XREF_BIBR XREF_BIBR XREF_BIBR XREF_BIBR."
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