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HCN4 activates HCN channels. 2 / 2

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"The knock-down of HCN4 in PHNs increased the speed of activation of endogenous HCN channels when compared to shScr treated neurons."

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"Our results suggest that HCN channels are mostly produced by the HCN4 isoform in heart, which contrasts with the sharp differences in the isoform stoichiometry in pituitary (15 HCN4 :2 HCN2 :1 HCN1 :1 HCN3), kidney (24 HCN4 :2 HCN3 :1 HCN2 :1 HCN1) and brain (3 HCN4 :2 HCN2 :1 HCN1 :1 HCN3)."

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HCN4 activates HCN channels. 2 / 2

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