IndraLab

Statements

USP13 binds RAF1. 4 / 4
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sparser
"USP13 interacts with Raf1."
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sparser
"A coimmunoprecipitation assay was performed in Flag-tagged Raf1 (Flag-Raf1)-overexpressing 46C mESCs carrying the HA or HA-USP13 transgene with a Flag antibody-affinity gel, which was used to bind the Flag fusion protein for immunoprecipitation analysis, to determine whether USP13 interacts with Raf1 ( xref A )."
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reach
"Mechanistically, we demonstrate that USP13 physically interacts with, deubiquitinates, and stabilizes serine/threonine kinase Raf1 and thereby sustains Raf1 protein at the posttranslational level to activate the FGF/MEK/ERK prodifferentiation signaling pathway in naive mouse ESCs."
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sparser
"Co-IP was performed and showed that RAF1 interacted with USP13 in hiPSCs ( xref G )."
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