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EPHA3 activates KCNH2. 3 / 3
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"In HEK cells stably overexpressing hERG1, we observed a hERG1 current density increase accompanied by V rest hyperpolarization after cell seeding onto FN."
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"We validate our microfluidics array platform in polystyrene (PS), cyclo-olefin polymer (COP) and poly (dimethylsiloxane) (PDMS) microchannels for drug induced disruption of hERG trafficking by culturing stably transfected HEK cells that overexpressed hERG (WT-hERG), and studying their morphology, proliferation rates, hERG protein expression, and response to drug treatment."
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"5 In addition, to distinguish whether compounds diminished hERG blockade directly, we developed secondary patch clamp assays that employed HEK cells that overexpressed hERG and another cell line that [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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