IndraLab

Statements

USP13 activates NASH. 4 / 4
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"These findings further reveal that adipocyte proliferation might links to the increased weight of visceral fat in NASH diet-challenged mice.3.4 Hepatocyte-specific Usp13 overexpression mitigates HFHC/WTDF-triggered NASH."
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"Given the close-knit correlation of IRHOM2 deactivation with ubiquitin-associated domains activity of USP13, to thoroughly study whether USP13–IRHOM2 interaction is necessary for the inhibitory function of USP13 against NASH progression, AAV8-TBG-loaded WT full-length Usp13 sequences vectors (AAV-TBG-Usp13) and AAV8-TBG-loaded Usp13 with UBA1/2 domain deletion vectors (AAV-TBG-Usp13 (ΔUBA)) was generated and used again to further explore the influence of USP13 with UBA1/2 mutants on HFHC-induced NASH pathologies in vivo (Fig. S18N)."
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"Also, we further indicated that UBC13-deletion dramatically decreased IRHOM2 ubiquitination, and USP13 could not exhibit suppressive effect on IRHOM2 ubiquitination in these in vitro experiments (Fig. 6M).3.9 Hepatocyte-specific Usp13 overexpression alleviates HFMCD-induced NASH."
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"The obtained results indicated that UBA domain of USP13 is essential for its suppressive effects in regulation of NASH development via IRHOM2 pathway.3.7 USP13-IRHOM2 interaction is necessary for USP13-triggered mitigation of NASH."
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