IndraLab

Statements

USP7 activates Cyclin. 3 / 3
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"Second, ectopic expression of USP7 increased the protein stability of ectopic cyclin F. To our surprise, however, the USP7-induced stability of cyclin F protein was independent of the deubiquitylase activity of USP7."
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"We tested if USP7 can rescue the APC/C substrates cyclin B1 and securin from degradation in mitotic extract."
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"We showed that USP7 promotes breast carcinogenesis by stabilizing PHF8 and upregulating cyclin A2 and that the interaction between USP7 and PHF8 is augmented during DNA damage."
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