IndraLab

Statements

Lamotrigine inhibits KCNK18. 6 / 6
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"Lamotrigine inhibits TRESK regulated by G protein coupled receptor agonists."
18190784
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"In COS-7 cells transfected with mouse TRESK, 30 microM lamotrigine inhibited TRESK by approximately 50%."
18190784
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"Lamotrigine, a Na channel blocker, and IBA, an alkylamide derivative of hydroxyl-α-sanshool, inhibit TRESK currents with an IC of 47 μM and ~500 μM, respectively [32,43]."
29973548
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"As previously described [39], lamotrigine 100 μM also blocked TRESK-mediated background currents by 46.9 ± 8.1% (p < 0.01; n = 6)."
21527011
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"Arachidonic acid (AA), lidocaine, and lamotrigine inhibited the activity of TRESK-like channel by 25 ± 6%, 77 ± 8%, and 46± 10%, respectively, in the cell-attached patches (Figure 3E, n = 5)."
29973548
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"The glutamate activated TRESK was blocked by lamotrigine in DRG neurons."
18190784