IndraLab

Statements

ATM phosphorylates USP15. 6 / 6
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"Here we found that ATM phosphorylates USP15 after DNA damage, affects USP15 recruitment to DNA damage sites, and BARD1–HP1γ interaction, and therefore regulates BARD1/BRCA1 retention at DNA damage sites."
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"Here we found that ATM phosphorylates USP15 after DNA damage, affects USP15 recruitment to DNA damage sites, and BARD1-HP1gamma interaction, and therefore regulates BARD1 and BRCA1 retention at DNA damage sites."
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"USP15 Ser678 is phosphorylated by ATM, which is essential for USP15 recruitment to DSBs."
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"As shown in Fig.  xref , USP15 was phosphorylated at ataxia telangiectasia-mutated (ATM) consensus Ser-Gln/Thr-Gln (SQ/TQ) sites after IR."
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"Thus, ATM-dependent USP15 phosphorylation has two effects: (1) affecting the sub-cellular localization of USP15, and (2) affecting the recruitment of USP15 to DSBs."
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"Finally, USP15 is phosphorylated by ATR and ATM and is known to cleave ubiquitin from IkappaB, thus dampening the NF-kappaB response (see below)."
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