IndraLab

Statements

ATM phosphorylates USP15. 8 / 8
| 4 4
reach
"Here we found that ATM phosphorylates USP15 after DNA damage, affects USP15 recruitment to DNA damage sites, and BARD1-HP1gamma interaction, and therefore regulates BARD1 and BRCA1 retention at DNA damage sites."
30874560
reach
"USP15 Ser678 is phosphorylated by ATM, which is essential for USP15 recruitment to DSBs."
30874560
reach
"Another study revealed that USP15 can be phosphorylated by ATM and recruited to sites of DNA damage."
39522000
sparser
"Thus, ATM-dependent USP15 phosphorylation has two effects: (1) affecting the sub-cellular localization of USP15, and (2) affecting the recruitment of USP15 to DSBs."
30874560
reach
"Finally, USP15 is phosphorylated by ATR and ATM and is known to cleave ubiquitin from IkappaB, thus dampening the NF-kappaB response (see below)."
19489724
sparser
"As shown in Fig.  xref , USP15 was phosphorylated at ataxia telangiectasia-mutated (ATM) consensus Ser-Gln/Thr-Gln (SQ/TQ) sites after IR."
30874560
sparser
"Here we found that ATM phosphorylates USP15 after DNA damage, affects USP15 recruitment to DNA damage sites, and BARD1–HP1γ interaction, and therefore regulates BARD1/BRCA1 retention at DNA damage sites."
30874560
sparser
"USP15 is important for homologous recombination and is phosphorylated by ATM in response to DNA double-strand breaks ( xref )."
40824090