IndraLab

Statements

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"Data suggest that pharmacological chaperones bind to the high affinity drug-binding site in the Kv11.1 pore to stabilize Kv11.1 channel conformations suitable for ER export into the secretory pathway ( xref ; xref ; xref ; xref ; xref )."
29875689
sparser
"We first chose the cardioprotective drug, resveratrol, which was used to correct trafficking defect caused by arsenic trioxide via acceleration of interaction between hERG and chaperones, and alleviation of ER stress. xref In addition, resveratrol shortened APD 50 and APD 90 recorded in freshly isolated guinea pig ventricular myocytes by inhibition of I ca-L and restoration of I kr when co-incubated with arsenic trioxide."
26543354
sparser
"Our findings suggested that the forward trafficking disruption was caused by the impairment of channel folding, which was associated with the changes in the interactions between hERG proteins and chaperones."
28763460
sparser
"These findings suggested that DHB-induced hERG trafficking defect results from protein misfolding, which may due to the reduction of Hsp90 expression and the aberrant interaction between hERG protein and molecular chaperones."
28763460
sparser
"The relative band density of 135 kDa hERG signal identified by anti-Hsp70 antibodies over that identified by an anti-hERG antibody was determined to indicate the changes of interactions between hERG and chaperones."
32064022
sparser
"Furthermore, forward trafficking was disrupted by impaired channel folding associated with altered interactions between hERG proteins and chaperones."
28763460
sparser
"Quantitative RT-PCR, Western blot analysis, immunofluorescence and co-immunoprecipitation methods were used to determine the effects of mitragynine on hERG1a/1b expression and hERG1-cytosolic chaperones interaction."
31874991
sparser
"The forward trafficking disruption was caused by impaired channel folding, which was associated with changes in the interactions between hERG proteins and chaperones."
28763460