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USP7 inhibits SOCS1. 3 / 3

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"Furthermore, we observed that deubiquitinase USP7 protein negatively regulates IFN-I-mediated antiviral activity by stabilizing suppressor of cytokine signaling 1 (SOCS1) (4)."

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"USP7 Small-molecule Inhibitors Enhance Type I-Interferon Antiviral Efficacy by Destabilizing SOCS1."

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"This process is believed to occur by destabilizing the suppressor of cytokine signaling 1 protein (SOCS1) that USP7 enhances stability through deubiquitination [122]."

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USP7 inhibits SOCS1. 3 / 3

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