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A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

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Statements

USP1 activates MYC. 2 / 2

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"We found that R1881 induced a significant increase in NKX3.1 (a positive control) transcript in RV1 cells, but it failed to induce the c-Myc transcript, and USP1 knockdown reduced the c-Myc or NKX3.1 transcript similarly, with or without R1881."

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"Taken together , these results indicate that USP1 promotes the expression of c-Myc by regulating KDM4A ."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...