IndraLab

Statements

USP13 leads to the phosphorylation of AKT. 3 / 3
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"Depletion of USP13 in breast cancer cells promoted AKT phosphorylation, cell proliferation, glycolysis, and tumor growth through downregulation of PTEN."
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"Similarly, depletion of USP13 downregulated PTEN protein and upregulated AKT and FOXO1/3 phosphorylation in MCF10A (XREF_FIG) and MCF7 (XREF_FIG) mammary epithelial cells and in HCT116 colon cancer cells (XREF_FIG), but not in the isogenic PTEN-null HCT116 cells (XREF_FIG)."
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"USP13 also protected BMSCs from MPS-induced apoptosis by modulating PTEN and reducing AKT phosphorylation."
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