IndraLab

Statements

2'-O-methyluridine inhibits BAP1. 2 / 2

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"Global DNA methylation was analyzed in 47 Class 1 and 45 Class 2 primary UMs and in UM cells engineered to inducibly deplete BAP1."

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reach

"The peculiar UM proneness in MBD4-mutant carriers (13 out of 23 carriers; XREF_TABLE) remains unexplained, but the fact that the frequent M3 in UM inactivates wild-type copies of both BAP1 and MBD4 suppressor genes may at least in part explain the frequent inactivation of MBD4 in UM."

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INDRA sources:

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IndraLab

Statements

2'-O-methyluridine inhibits BAP1. 2 / 2

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