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This Service

A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

2'-O-methyluridine inhibits BAP1. 2 / 2

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"Global DNA methylation was analyzed in 47 Class 1 and 45 Class 2 primary UMs and in UM cells engineered to inducibly deplete BAP1."

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"The peculiar UM proneness in MBD4-mutant carriers (13 out of 23 carriers; XREF_TABLE) remains unexplained, but the fact that the frequent M3 in UM inactivates wild-type copies of both BAP1 and MBD4 suppressor genes may at least in part explain the frequent inactivation of MBD4 in UM."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...