IndraLab

Statements


Emodin inhibits TRAF6. 3 / 3
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"Previous studies have indicated that emodin inhibited the angiogenesis and metastasis of ATC by regulating TRAF6 mediated pathways, including the TRAF6/CD147/MMP9 pathway [XREF_BIBR]."
| PMC

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"Adequate emodin treatment inhibited both TRAF6/HIF-1α/VEGF and TRAF6/CD147/MMP9 axes to block cell metastasis and angiogenesis in human anaplastic thyroid cancer cell lines in vitro and in vivo [119]."

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"Therefore, we determined the expression levels of these related proteins, and the results indicated that emodin could significantly downregulate the HTRA1, IL-33, MyD88, TRAF-6, and NF-kappaB protein levels, but upregulate the TGF-beta1 protein level, and decrease the TNF-alpha, IL-1beta, and IL-6 mRNA levels."