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USP28 inhibits E3_Ub_ligase. 2 / 2

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"USP28 was shown to bind c-Myc through an interaction with FBW7alpha and antagonize its E3 ligase activities in the nucleus, leading to Myc stabilization and tumor cell proliferation."

29527331

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"USP28 antagonizes FBW7, an F-box protein and an important component of the SKP1-CUL1-F-BOX (SCF)-type E3 ubiquitin ligase that targets key transcriptional factors to ubiquitin-directed proteasome degradation."

29415985

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IndraLab

Statements

USP28 inhibits E3_Ub_ligase. 2 / 2

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