IndraLab

Statements

USP22 inhibits USP22. 5 / 5
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"However, the increase in SIRT1 levels enhances its deacetylation activity, which in turn, deacetylates USP22 and other SAGA components, thereby decreasing the enzymatic activity of USP22 ."
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"Lastly, ubiquitylation of USP22 mediated by the anaphase promoter complex and cyclosome (APC/C) induces USP22 protein degradation during the cell cycle [XREF_BIBR]."
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"Supporting the regulation of USP22 by m A modification, knockdown of the methyltransferase METTL3 increased USP22 expression in ALKBH5-silenced 143B cells (Fig. 4H; Supplementary Fig. S9A)."
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"Loss of USP22 leads to upregulation of many ISGs, some with important functions in viral defense, like OAS1, -2 and -3, MX1 and IFI27, suggesting a potential role of USP22 in the regulation of IFN signaling and viral responses (Fig. 2B)."
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"Stimulation with EPI markedly reduced USP22 ubiquitination levels (Fig. 5A), supporting our speculation that EPI protects USP22 from ubiquitination-mediated degradation."
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