IndraLab

Statements

PTK2B binds SIRPA. 6 / 6
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"We reconstituted the interaction of SHPS-1 with either PYK2 or SKAP55hom/R ()."
10469599
sparser
"The inhibition of necroptosis caused by SIRPα deficiency requires PTK2B activity, and the C-terminal domain of SIRPα directly interacts with PTK2B, inhibiting its activation in macrophages [ xref ]."
39192326
reach
"Pyk2 recruitment to SHPS-1 is mediated via the interaction of Pyk2 Tyr402 and the Src in response to IGF-I."
20521079
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"Thus, Pyk2 recruitment to SHPS-1 plays an important role in regulating the IGF-I-stimulated mitogenic response."
20521079
reach
"Recruitment of Pyk2 to SHPS-1 signaling complex is required for IGF-I-dependent mitogenic signaling in vascular smooth muscle cells."
20521079
reach
"Skaphom, ADAP and Pyk2 associate constitutively with Shps1, but become tyrosyl phosphorylated upon adhesion [34]."
12826400