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Iloperidone inhibits KCNH2. 6 / 6
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"Iloperidone inhibited the hERG 1A/3.1 tail currents at -50 mV in a concentration-dependent manner with an IC50 value of 0.44 μM."
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"Average reduction of HERG tail current amplitude by iloperidone 100 nmol/L was 31.5 +/- 5.7%."
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"Iloperidone also induced a rapid and reversible inhibition of hERG 1A/3.1 tail currents during repolarization."
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"Our results indicated that iloperidone concentration-dependently inhibited hERG 1A/3.1 currents by preferentially interacting with the open states of channels, but not by the disruption of membrane trafficking or surface membrane expression of hERG 1A and hERG 1A/3.1 channel proteins."
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"Among these ten drugs, fluspirilene, umeclidinium, and iloperidone have been reported to be associated with cardiac issues and were found to inhibit the human hERG potassium channel."
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"Our results show two interesting new findings : (1) that iloperidone prolongs cardiac repolarization in a reverse rate dependent manner by blocking the HERG current and (2) that a single oral administ[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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