IndraLab

Statements

SCN4A inhibits sodium(1+). 3 / 3
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"Our data suggest that the presence of an SCN4A gene variant that impairs sodium channel function exacerbates an infant 's vulnerability."
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"Lower levels of SCN1A, SCN2A, SCN3A, SCN4A and SCN8A expression have also been reported in heart and shown to contribute approximately 23% of the total functional sodium channels in mouse ventricular myocytes and 27% in human atrial myocytes, based on TTX sensitivity."
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"The mutation R1448C of gene SCN4A slows down the inactivation rate of the skeletal muscle sodium channel and invalidates rapid recovery from inactivation XREF_BIBR."
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