IndraLab

Statements

BAP1 inhibits XRCC1. 5 / 5
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"In contrast to BAP1, which inhibits RCC by upregulation of STING activity and activation of interferon, UCHL5 promotes RCC by regulating immune infiltration and antigen presentation of B cells, and its increased level in RCC blood samples suggest its potential as a prognostic marker."
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"BAP1-TPDS is associated with an increased risk of a specific skin lesion, BAP1-inactivated melanocytic tumour (BIMT) (34), cutaneous melanoma (CM) (34), renal cell carcinoma (RCC) (35), and basal cell carcinoma (BCC) (36)."
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"Truncation mutations in BAP1, disrupting its peptidase region, were the predominant characteristics of kidney cancer.Additionally, we discovered the underlying biochemical mechanism by which BAP1 suppresses RCC development."
39034372
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"In conclusion, our findings suggest that BAP1 suppresses RCC by regulating a series of biological processes, including the STING -involved IFN-I pathway."
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"BAP1 knockout in mice leads to MM growth, larger tumors and increased number of metastases and BAP1 protein expression is also correlated with poor prognosis and shorter survival in RCC and cholangiocarcinoma, as well as UM (22–25)."
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