IndraLab

Statements

BAP1 deubiquitinates SLC7A11. 8 / 8
| 8
reach
"At the SLC7A11 promoter, BAP1 deubiquitinates H2Aub and subsequently inhibits the expression of SLC7A11."
34992680
reach
"BAP1 deubiquitinates histone 2A (H2Aub) on the SLC7A11 promoter and represses SLC7A11 expression in a p53-independent way (39, 40)."
39290692
reach
"BAP1 represses solute carrier family 7 member 11 (SLC7A11) expression by reducing H2A ubiquitination of the SLC7A11 promoter, resulting in lipid peroxidation and ferroptosis (Zhang et al., 2019)."
39748950
reach
"Given that miR-31-5p has been shown to reduces DOX-induced cardiac toxicity [16], we investigated the role of the targeted relationship between miR-31-5p and BAP1 in SCM.Against this background, it is clear that the regulation of SLC7A11 deubiquitination by BAP1 may have an impact on ferroptosis in SCM."
38816686
reach
"To determine whether BAP1 induced the deubiquitination of SLC7A11, the deubiquitination enzyme inhibitor G5 was added to examine its effect on the ubiquitination level of SLC7A11."
38816686
reach
"These findings imply that BAP1 induces the deubiquitination of SLC7A11, thereby inhibiting its expression."
38816686
reach
"As shown above, BAP1 promotes the deubiquitination of SLC7A11, leading to ferroptosis in H9C2 cells."
38816686
reach
"BRCA1-associated protein 1 (BAP1) decreases SLC7A11 promoter H2A ubiquitination via an H2A deubiquitinase that functions as a tumor suppressor."
36281949