IndraLab

Statements

USP6 binds RRBP1. 4 / 4
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"For RRBP1-USP6 fusions with abnormal ubiquitination regulation, proteasome inhibitors or deubiquitinating enzyme inhibitors can be explored ( xref )."
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"Furthermore, a recent study has identified an RRBP1-USP6 fusion in low-grade myofibroblastic sarcoma ( xref ) ( xref )."
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"These cases were investigated with RNA-sequencing, and a RRBP1::USP6 translocation was detected in one."
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"In conclusion, RRBP1 drives tumor malignancy through fusion with ALK or USP6 genes and the RRBP1-ALK fusion might enhance cancer cell survival and invasiveness through ER localization, whereas the RRBP1-USP6 fusion aberrantly activates ubiquitination regulation, thus suggesting an association between ER-ribosome pathway dysregulation and tumor progression."
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