IndraLab

Statements

Ubiquitin activates UCHL5. 3 / 3
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"The 26S proteasome-mediated degradation of a ubiquitinated protein target involves an initial Ub recognition step that is primarily mediated by subunits Rpn10 and Rpn13 of the 19S RP [8,9], followed by deubiquitination of the substrate by Rpn11 or one of two other proteasome-associated deubiquitinating enzymes (DUBs), UCH37 and USP14."
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"Recently it was reported that UCH37 activity is stimulated by branched ubiquitin chain architectures."
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"It associates with the 19S RP via the Rpn13 subunit, the proteasomal ubiquitin receptor that activates Uch37 deubiquitylating activity."
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