IndraLab

Statements


USP4 activates PDCD4. 3 / 3
| 3

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"In addition, proteasome inhibition by the addition of MG132 induced a significant increase in the PDCD4 expression level (XREF_FIG), suggesting that USP4 inhibits PDCD4 degradation."

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"To determine whether PDCD4 is involved in the anti-proliferative function of USP4, we further examined the role of PDCD4 in the USP4 induced inhibition of proliferation by knocking down PDCD4 using siRNA."

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"The physical interaction between USP4 and PDCD4 indicated that USP4 targets PDCD4 for deubiquitination and subsequent inhibition of its degradation."